There are many transcripts of human protein-coding genes identified through massive NGS sequence datasets. Alternative transcripts would provide diversified molecular functions in biological processes during development and evolution. It is essential for biomedical researchers to further interrogate the expression profiles of various transcripts in different tissues. In this study, we have utilized the GTEx dataset to thoroughly investigate the expression patterns of dominantly expressed transcripts in more than fifty normal human tissue types. Identification of tissue representative transcripts would be beneficial for understanding the biological functions of protein-coding genes in particular tissues. Herein, we designed the RTTPG database to list the tissue representative highly expressed transcripts of human protein-coding genes with particularly easy-to-use visualization interfaces. We previously reported that most of the human protein-coding genes maintain few dominant transcripts in terms of expression modulation. Thus, we provided the visualized tissue expression profiles of the top-ranked transcripts as well as defined preferential tissue expressed transcripts by the Z-score values. In the beginning tissue distribution graph below: Tissue specific representative transcripts of human protein-coding genes were noted by their Rank1 transcripts with the Z-score above three. Selecting the tissue subtypes will display the numbers of tissue representative gene transcripts.

Z-score ≥ 3; Rank1